Finding a cure for cancer is the biggest challenge of the 21st century
Cancer is a multifactorial disease that shows tremendous temporal variability. Among cancers, epithelial cancers are the most prevalent form of cancer among adults. In fact breast and prostate cancer account for most of cancer-related deaths in female and male population, respectively. Majority of cancer related fatalities can be attributed to metastasis of the primary tumor to another organ, most commonly to bone and lungs. The difficulty in detecting small populations of tumor cells in an organ distal to the primary tumor makes treating cancer very challenging as these secondary tumors i.e., metastasis may lay dormant and get activated much later in a rather unpredictable fashion. Although many serum and urine markers have been identified for staging tumors the availability of markers to detect tumor metastasis are missing. Our efforts are focused on understanding the biological signals the promote metastasis of breast and prostate cancer to bone and developing new targets for early diagnosis and treatment of metastasis.
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