Our Discoveries

2005 - In Vivo Bioreactor - A novel paradigm for in vivo engineering of autologous bone without cell transplantation or growth factor administration. This remains to the date the only example of bone engineering where all cues are derived endogenously.
2008 - Cell shape and function can be controlled and modulated by stochastic nanoroughness
2010 - First and the only example of engineering cartilage de novo without cell transplantation or growth factor administration.
2013 - α-helix to β-sheet switch in secondary structure in polysaccharides
2013 - Discovery of the role of mechanobiology in apical-basal polarization of endothelial cells and organization into lumens
2014 - Physicochemical paradigm for nanoparticle uptake via Caveolae/Lipid Rafts
2014 - Discovery of Piezo-1 in neuron-astrocyte interaction and in sensing of stochastic nanoroughness (nanotopography)
2015 - Activation of MMP-9 by Cathepsin-K
2017 - Phosvitin - an avian phosphoprotein is involved in bone mineral phase formation during development
2017 - Low-PII- helix disordered conformation in phosphoproteins is critical for hydroxyapatite biomineralization
2018 - Cancer cell membrane stiffness impacts Dynamin-2 mediated endocytosis
2018 - Discovery of calcium sensing receptor (CaSR) in bone formation by mesenchymal stem cells (MSCs)
2019 - Autonomous-mechanobiology in regulation of chondrogenesis in human MSCs
2019 - Discovery of Piezo1+/CD11b+ circulating monocytes
2019 - Discovery of mechanobiology paradigm in the stabilization of blood vessels