Our Discoveries
- 2005 - In Vivo Bioreactor - A novel paradigm for in vivo engineering of autologous bone without cell transplantation or growth factor administration. This remains to the date the only example of bone engineering where all cues are derived endogenously.
- 2008 - Cell shape and function can be controlled and modulated by stochastic nanoroughness
- 2010 - First and the only example of engineering cartilage de novo without cell transplantation or growth factor administration.
- 2013 - α-helix to β-sheet switch in secondary structure in polysaccharides
- 2013 - Discovery of the role of mechanobiology in apical-basal polarization of endothelial cells and organization into lumens
- 2014 - Physicochemical paradigm for nanoparticle uptake via Caveolae/Lipid Rafts
- 2014 - Discovery of Piezo-1 in neuron-astrocyte interaction and in sensing of stochastic nanoroughness (nanotopography)
- 2015 - Activation of MMP-9 by Cathepsin-K
- 2017 - Phosvitin - an avian phosphoprotein is involved in bone mineral phase formation during development
- 2017 - Low-PII- helix disordered conformation in phosphoproteins is critical for hydroxyapatite biomineralization
- 2018 - Cancer cell membrane stiffness impacts Dynamin-2 mediated endocytosis
- 2018 - Discovery of calcium sensing receptor (CaSR) in bone formation by mesenchymal stem cells (MSCs)
- 2019 - Autonomous-mechanobiology in regulation of chondrogenesis in human MSCs
- 2019 - Discovery of Piezo1+/CD11b+ circulating monocytes
- 2019 - Discovery of mechanobiology paradigm in the stabilization of blood vessels