Selected Publications
S. Xiang, M. Sarem, S. Shah, V. P. Shastri
"Liposomal Treatment of Cancer Cells Modulates Uptake Pathway of Polymeric Nanoparticles by Altering Membrane Stiffness" Small (2018) (DOI: 10.1002/smll.201704245) |
M. Sarem, N. Arya, M. Heizmann, A. T. Neffe, A. Barbero, T. P. Gebauer, Ivan Martin, Andreas Lendlein, V. P. Shastri
"Interplay between stiffness and degradation of architectured gelatin hydrogels leads to differential modulation of chondrogenesis in vitro and in vivo" Acta Biomaterialia (2018) (DOI: 10.1016/j.actbio.2018.01.025) |
A. Forget, A. Blaeser, F. Miessmer, M. Köpf, D. F. Duarte Campos, N. H. Voelcker, A. Blencowe, H. Fischer and V. P. Shastri
"Mechanically Tunable Bioink for 3D Bioprinting of Human Cells" Advanced Healthcare Materials (2017) (DOI:10.1002/adhm.201700255) |
M. Sarem, St. Lüdeke, R. Thomann, P. Salavei, Z. Zou, W. Habraken, A. Masic and V. P. Shastri
"Disordered Conformation with Low PII Helix in Phosphoproteins Orchestrates Biomimetic Apatite Formation" Advanced Materials (2017) (DOI:10.1002/adma.201701629) AdvancedScienceNews highlight |
M. Bosetti, A. Borrone, M. Leigheb, V. P. Shastri and M. Cannas
"Injectable graft substitute active on bone tissue regeneration" Tissue Engineering Part A (2017) (DOI:10.1089/ten.tea.2016.0554) |
M. Sarem, D. Vonwil, S. Lüdeke and V.P. Shastri "Direct Quantification of Dual Protein Adsorption Dynamics in Three Dimensional Systems in Presence of Cells" Acta Biomaterialia (2017) (DOI:10.1016/j.actbio.2017.05.021) Click here for PDF |
A. Rüther, A. Forget, A. Roy, C. Carballo, F. Mießmer, R.K. Dukor, L.A. Nafie, Ch. Johannessen, V.P. Shastri and S. Lüdeke
"Unravelling a Direct Role for Polysaccharide β‐Strands in the Higher Order Structure of Physical Hydrogels" Angewandte Chemie, 129 (16), 4674-4678 (2017) (DOI: 10.1002/ange.201701019) |
L.A.J. Ahrens, D. Vonwil, J. Christensen and V.P. Shastri
"Gelatin device for the delivery of growth factors involved in endochondral ossification" PloS one, 12 (4), e0175095 (2017) (DOI:10.1371/journal.pone.0175095) |
A. Forget, N. Arya, R. Randriantsilefisoa, F. Miessmer, M. Buck, V. Ahmadi, D. Jonas, A. Blencowe and V.P. Shastri
"Nonwoven Carboxylated Agarose-Based Fiber Meshes with Antimicrobial Properties" Biomacromolecules, 17 (12), 4021-4026 (2016) (DOI: 10.1021/acs.biomac.6b01401) |
N. Ninan, A. Forget, V.P. Shastri, N.H. Volcker and A. Blencowe
"Antibacterial and Anti-Inflammatory pH-Responsive Tannic Acid-Carboxylated Agarose Composite Hydrogels for Wound Healing" ACS Applied Materials & Interfaces, 8 (42), 28511-28521(2016) (DOI:10.1021/acsami.6b10491) |
P.P. Wyss, L.C. Herrera, N.S. Bouteghmes, M. Sarem, W. Reichardt, J. Leupold, J. Hennig and V.P. Shastri
"Nanoprobes for Multimodal Visualization of Bone Mineral Phase in Magnetic Resonance and Near-Infrared Optical Imaging" ACS Omega, 1 (2), 182-192 (2016) (DOI:10.1021/acsomega.6b00088) |
S.P. Lamichhane, N. Arya, E. Kohler, S. Xiang, J. Christensen and V.P. Shastri
"Recapitulating epithelial tumor microenvironment in vitro using three dimensional tri-culture of human epithelial, endothelial, and mesenchymal cells" BMC cancer, 16 (1), 581 (2016) (DOI:10.1186/s12885-016-2634-1) |
P.P. Wyss, S. Lamichhane, M. Rauber, R. Thomann, K.W. Krämer and V.P. Shastri
"Tripod USPIONs with high aspect ratio show enhanced T2 relaxation and cytocompatibility" Nano medicine, 11 (9), 1017-1030 (2016) (DOI:10.2217/nnm.16.8) |
M. Heiny and V.P. Shastri
"Nanofibers of Elastin and Hydrophilic Segmented Polyurethane Solution Blends Show Enhanced Mechanical Properties through Intermolecular Protein–Polymer H Bonding" Biomacromolecules, Published Online March 3, 2016 (DOI: 10.1021/acs.biomac.5b01681) |
I.E. Paulus, M. Heiny, V.P. Shastri and A. Greiner
"Chemical vapour deposition of soluble poly(p-xylylene) copolymers with tuneable properties" Polymer Chemistry, 7 (1), 54-62 (2016) (DOI: 10.1039/C5PY01343G) |
M.I. Saga, E. Nicoli, E.Kohler and V.P. Shastri
"Albumin Incorporation in Polyethylenimine–DNA Polyplexes Influences Transfection Efficiency" Biomacromolecules, Published Online December 11, 2015 (DOI: 10.1021/acs.biomac.5b01308) |
J. Christensen and V.P. Shastri
"Matrix-metalloproteinase-9 is Cleaved and Activated by Cathepsin-K" BMC Research Notes, Published Online July 29, 2015 (doi:10.1186/s13104-015-1284-8) Click here for PDF |
J. Christensen, Vonwil and V.P. Shastri
"Non-Invasive In Vivo Imaging and Quantification of Tumor Growth and Metastasis in Rats Using Cells Expressing Far-Red Fluorescence Protein" PLOS One, Published Online July 17, 2015 (DOI:10.1371/journal.pone.0132725) Click here for PDF |
V.P. Shastri
"Biomineralization: A Confluence of Materials Science, Biophysics, Proteomics and Evolutionary Biology" MRS Bulletin, 40(6) 474 - 477 (2015) (DOI: 10.1557/mrs.2015.118) |
M. Sarem and S. Luedecke
"Circular Dichroism: A Powerful Tool for Studying Biomineralization Promoter Proteins" MRS Bulletin, 40(6) 490 - 498 (2015) (DOI: 10.1557/mrs.2015.116) |
E. Nicoli, M.I. Syga, M. Bossetti, and V.P. Shastri
"Enhanced Gene Silencing through Human Serum Albumin-Mediated Delivery of Polyethyleneimine-siRNA Polyplexes" PLOS One, Published Online April 9, 2015 (DOI:10.1371/journal.pone.0122581) Click here for PDF |
M. Heiny and V.P. Shastri
"Cyclic Comonomers for the Synthesis of Carboxylic Acid and Amine Functionalized Poly(l-lactic Acid)" Molecules 20(3), 4764-4779 (2015) Published online March 16, 2015 (DOI:10.3390/molecules20034764) Click here for PDF |
S.P. Lamichhane, N. Arya, N. Ojha, E. Kohler and V.P. Shastri
"Glycosaminoglycan-Functionalized Poly-Lactic-co-Glycolide Naoparticle: Synthesis, Characterization, Cytocompatibility and Cellular Uptake" Int. Journal of Nanomedicine, Published Online January 19, 2015 ( DOI: 10.2147/IJN.S73508), Vol 10, 775-789 |
N. Blumenthal, O. Hermanson, B. Heimrich and V.P. Shastri
"Stochastic Nanoroughness Modulates Neuron-Astrocyte Interactions and Function via Mechanosensing Cation Channels" Proc. Natl. Acad. Sci. USA, Published online October 27, 2014 (DOI: 10.1073/pnas.1412740111) Write up on the MRC-UK website link Click here for the University Press Release |
A. Forget, R-A Pique, V. Ahmadi, S. Lüdeke and V.P. Shastri
"Mechanically Tailored Agarose Hydrogels through Molecular Alloying with β Sheet Polysaccharides" Macromolecular Rapid Communications, Article first published online: 22 SEP 2014 DOI: 10.1002/marc.201400353 |
N.S. Teske, J. Voigt, and V. P. Shastri
"Clickable Degradable Aliphatic Polyesters via Copolymerization with Alkyne Epoxy Esters: Synthesis and Postfunctionalization with Organic Dyes" JACS, Published online, June 27, 2014 (DOI: /10.1021/ja505629w) |
J. Voigt, J. Christensen, V. P. Shastri
"Differential uptake of nanoparticles by endothelial cells through polyelectrolytes with affinity for caveolae" Proc. Natl. Acad. Sci. USA, Published online February 25, 2014 (DOI: 10.1073/pnas.1322356111) |

J. J. Wurth, N. R . Blumenthal, V. P. Shastri
"Hydrophilization of Poly(Caprolactone) Copolymers through Introduction of Oligo(Ethylene Glycol) Moieties"
PLOS ONE, Published online, June 16, 2014 ( DOI: 10.1371/journal.pone.0099157)

D. Vonwil, J. Christensen, S. Fischer, O. Ronneberger, V. P. Shastri
"Validation of Fluorescence Molecular Tomography/Micro-CT Multimodal Imaging In Vivo in Rats"
Mol Imaging Biol, Published online, October 26, 2013 ( DOI: 10.1007/s11307-013-0698-8)
A. Forget, J. Christensen, S. Lüdeke, E. Kohler, S. Tobias, M. Matloubi, R. Thomann, , V. P. Shastri
"Polysaccharide hydrogels with tunable stiffness and provasculogenic properties via α-helix to β-sheet switch in secondary structure" Proc. Natl. Acad. Sci. USA, Published online, July 25 2013 (DOI: 10.1073/pnas.1222880110) |
P.J. Emans, L.W. van Rhinjna, T.J.M. Welting, A. Cremers, N. Wijnands, F. Spaaapen, J.W. Voncken and V. P. Shastri
“Autologous engineering of cartilage” Proc. Natl. Acad. Sci. USA, Published Online Feb 4, 2010 (2010) (DOI: 10.1073/pnas.0907774107 ) Featured on BMBF Website: http://www.biotechnologie.de/BIO/Navigation/DE/root,did=107832.html?listBlId=74462& |
T. Soike, A. Streff, C. Guan, R. Ortega, M. Tantawy, C. Pino and V. P. Shastri
“Engineering a Material Surface for Drug Delivery and Imaging using Layer-by-Layer Assembly of Functionalized Nanoparticles” Advanced Materials, Published online Feb 9, 2010 (2010). (DOI: 10.1002/adma.200903069) Commentary in Nature Materials: P.T. Hammond, Particles Release, Nature Materials, 9, 292-293 (2010) |
J. C. Sy, A. Klemm and V. P. Shastri
“Emulsion-Based Control of Electrospun Polymer Fibers” Advanced Materials, 21, 1814 (2009), (DOI: 10.1002/adma.200701630) |
A.M. Lipski, C. Pino F.R. Haselton, I-W. Chen and V. P. Shastri
“The effect of silica nanoparticle-modified surfaces on cell morphology, cytoskeletal organization and function”, Biomaterials, October 29(28), 3836(2008) (DOI: doi:10.1016/j.biomaterials.2008.06.002) |

M.M.
Stevens, R.P. Marini, J. Aronson, D. Schaefer, R. Langer and V.P. Shastri
“In vivo engineering of organs: The bone bioreactor”
Proc. Natl. Acad. Sci. USA, 102(32), 11450-11455 (2005)
“In vivo engineering of organs: The bone bioreactor”
Proc. Natl. Acad. Sci. USA, 102(32), 11450-11455 (2005)

M.M.
Stevens, H. Qanadilo, R. Langer, I. Martin, and V.P. Shastri
"FGF-2 in combination with TGF-ß1 enhances periosteum-derived chondrogenesis in vitro"
J. Orthop. Res., 22, 1114-1119 (2004). DOI: 10.1016/j.orthres.2003.12.021
"FGF-2 in combination with TGF-ß1 enhances periosteum-derived chondrogenesis in vitro"
J. Orthop. Res., 22, 1114-1119 (2004). DOI: 10.1016/j.orthres.2003.12.021

P. J.
Lee, R. Langer, and V.P. Shastri
"Novel microemulsion enhancer formulation for simultaneous transdermal delivery of hydrophilic and hydrophobic drugs."
Pharm. Res., 20(2), 261-267 (2003).
"Novel microemulsion enhancer formulation for simultaneous transdermal delivery of hydrophilic and hydrophobic drugs."
Pharm. Res., 20(2), 261-267 (2003).

I. Martin,
V.P. Shastri, R. Padera, R. Langer, J. Yang, A. MacKay, G.
Vunjak-Novakovic, and L. Freed.
"Selective in vitro differentiation of mammalian mesenchymal progenitor cells into three dimensional skeletal tissues."
J. Biomed. Mat. Res., 55(2), 229-235 (2001).
"Selective in vitro differentiation of mammalian mesenchymal progenitor cells into three dimensional skeletal tissues."
J. Biomed. Mat. Res., 55(2), 229-235 (2001).

V.P.
Shastri, I. Martin, and R. Langer
"Macroporous polymeric foams by hydrocarbon templating." Proc. Natl. Acad. Sci. USA, 97(5), 1970-75 (2000).
"Macroporous polymeric foams by hydrocarbon templating." Proc. Natl. Acad. Sci. USA, 97(5), 1970-75 (2000).

K.S.
Anseth, V.R. Shastri and R. Langer
“Photopolymerizable Degradable Polyanhydrides”
Nature Biotechnology, 17(2), 156-159 (1999)
“Photopolymerizable Degradable Polyanhydrides”
Nature Biotechnology, 17(2), 156-159 (1999)

C.E.
Schmidt*, V.R. Shastri*, J.P. Vacanti and R. Langer
“Stimulation of Neurite Outgrowth Using Electrically Conducting Polymer”
Proc. Nat. Acad. Sci. USA, 94, 8948-8953 (1997), *Equally Contributing Authors
“Stimulation of Neurite Outgrowth Using Electrically Conducting Polymer”
Proc. Nat. Acad. Sci. USA, 94, 8948-8953 (1997), *Equally Contributing Authors