Stem Cell Niche
Cells in our body reside in very well defined environments and never in isolation. Their environment is composed of macromolecules (ECM) that forms the support framework, soluble cues in the form of growth factors, chemokines and cytokines, and other cells. The ECM also additionally serves to sequester and temporally and spatially immobilize soluble signals and provides a means for mechanical forces to be imposed on and sensed by cells. The microenvironment of totipotent (embryonic stem (ES) cells, induced pluripotent stem (IPS) cells) and pluripotent stem cells, that natures these cells and drives self-renewal in a living system is still very poorly understood, and deciphering the participants in the microenvironment, and unravelling their relationship and function is at the frontier of cell biology.
Our efforts are focused on:
- understanding the role of MSC heterogeneity in MSC niche maintenance and development of a synthetic system that will promote MSC self-renewal.
- developing testable evidence-based hypothesis to understand the formation of memory and the origins of neurodegenerative pathologies.
- B-cell and T-cell self-renewal and activation
Copyright - Shastrilab, All Rights Reserved
Our efforts are focused on:
- understanding the role of MSC heterogeneity in MSC niche maintenance and development of a synthetic system that will promote MSC self-renewal.
- developing testable evidence-based hypothesis to understand the formation of memory and the origins of neurodegenerative pathologies.
- B-cell and T-cell self-renewal and activation
Copyright - Shastrilab, All Rights Reserved
